The specific advantages of the two TEFOR’s models are the accessibility of their eggs, embryos, or larvae, which allow developing various studies. Both species share numerous physiological features and similar genetic tools.
Zebrafish (Danio rerio
) constitutes an alternative compromise when greater relatedness to humans is warranted. Also, the advantages of zebrafish in preclinical toxicity screenings and research are numerous.
Fruitfly (Drosophila melanogaster
) is one of the most tractable multicellular organisms for genetic analysis. The success of Drosophila melanogaster as a model organism was so far largely due to the power of forward genetic screens to identify the genes that are involved in a biological process. Recent emergence of genome editing methods will boost or complement these approaches.
Although tefor is currently centered on these two model species, it will be open to other model species all along its evolution, especially through the EFOR network (http://www.efor.fr/).
TEFOR wishes to support research through the establishment of research calls via its own budget or in collaboration with other infrastructures, or other partners such as the fondation maladies rares. Furthermore, TEFOR aims at coordinating the creation of a novel european infrastructure, open to other model species, such as xenopus, chicken or quails...