TEFOR is aimed at supporting research on two non mammalian model species: zebrafish and fruitfly. Through its network EFOR and other activities it also aims at making available progress for other model species when possible.
TEFOR is a distributed infrastructure which was founded in 2012 following the award of a French 'Grand Emprunt' grant. It is promoted by three founder research organisms (CNRS, INRA, INSERM) as well as the University of Auvergne.
By providing  readily accessible services and resources and promoting the use of models raising fewer ethical concerns, TEFOR is of major interest to support both public and private research.
TEFOR proposes integrated services in transgenesis, 3D image acquisition and annotation focusing on the zebrafish (Danio rerio) and the fruitfly (Drosophila melanogaster).
In this context TEFOR performs technological research and development and establishes useful programs for the communities working on these models.
TEFOR is administrated by a single office (“Infrastructure Office”) assisted by an Executive Board, composed by all the involved Directors.
By this office, TEFOR:
- provides integrated communication and scientific tools
- makes significant effort to spread its leading technologies to diverse scientific communities
- disseminates the general concepts and objectives of the distributed infrastructure
- valorizes the progress accomplished during its development
- integrates services by providing pluri-institutional administrative procedures (unique front desk for the customer for invoices and quotations) and establishes Customer Relationship Management tools (such as multi-platforms service tracking tools).
TEFOR is centered around the coordinated activities of two core platforms respectively dedicated to zebrafish and drosophila hunsbandry, transgenesis and mutagenesis: AMAGEN and Fly Facility.
Both are surrounded by nine partners:
- Upstream, two platforms support the infrastructure by developing cutting edge molecular biology technologies : TACGene (production of TALE and CRISPR/Cas9 nucleases), BM-Gif (standard molecular biology services), Transgenesis Rats PlatForm for the optimization of TALE and CRISPR nucleases in other models (rats in particular),
- the two platforms establish partnerships for the phenotyping: TEFOR Core Facility (TCF), LPGP, and VIM for zebrafish phenotyping, and N&D-ROUYER’s lab for Drosophila phenotyping.
- Finally, three partners establish key tools for the visibility of the infrastructure such as a 3D image database and tools: TCF, BioEmergences and IJPB.
TEFOR is administrated by a single office.
An effective management structure ensures the follow up of TEFOR activities.
TEFOR management is composed by four committees:
- The Supervising Board (« Comité des tutelles ») addresses the strategic needs, anticipates the development of all activities of TEFOR and constitutes the ultimate management and decision making body of the infrastructure.
- The Executive Board (“Comité éxecutif”) constitutes the steering committee.
- The Scientific Advisory Board (“Comité Consultatif Externe”) consists in external leading experts who will provide strategic inputs of the TEFOR infrastructure. - The Users Committee (“Comité des utilisateurs”) acts as the external representative of the users from both the academic and private scientific.
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Guidance on the environmental risk assessment of genetically modified animals
PITCh-ing an Alternative Knock-in Strategy for TALENs and CRISPR/Cas9
EFOR - Réseau d'´Étude Fonctionnelle chez les ORganismes modèles
CRISPR Cas9: A novel approach to genetic engineering
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